Instructor in Radiology
Email: DKORENCHAN@mgh.harvard.edu
Website(s)
Biography
The leitmotif of Dr. Korenchan's research is obtaining molecular and metabolic information with magnetic resonance imaging. His current work focuses on developing chemical exchange saturation transfer (CEST) MRI approaches for reporter gene imaging to monitor gene-based therapies and glutamate measurement in the brain, as well as novel imaging contrasts and methodologies for low magnetic field, accessible MRI scanners. He has previously developed hyperpolarized ¹³C imaging techniques for non-invasive pH mapping in prostate cancer and established novel ³¹P nuclear singlet order methods for metabolic spectral editing of NAD⁺/NADH.Recent Publications
- Marr KA, Korenchan DE, Jerschow A. Influence of Magnesium Ion Binding on the Adenosine Diphosphate Structure and Dynamics, Investigated by 31P NMR and Molecular Dynamics Simulations. J Phys Chem B. 2024 Sep 19. 128(37):8966-8973
- Scalzitti N, Miralavy I, Korenchan DE, Farrar CT, Gilad AA, Banzhaf W. Computational peptide discovery with a genetic programming approach. J Comput Aided Mol Des. 2024 Apr 03. 38(1):17
- Mu C, Liu X, Kim Y, Riselli A, Korenchan DE, Bok RA, Delos Santos R, Sriram R, Qin H, Nguyen H, Gordon JW, Slater J, Larson PEZ, Vigneron DB, Kurhanewicz J, Wilson DM, Flavell RR. Clinically Translatable Hyperpolarized 13C Bicarbonate pH Imaging Method for Use in Prostate Cancer. ACS Sens. 2023 11 24. 8(11):4042-4054
- Scalzitti N, Miralavy I, Korenchan DE, Farrar CT, Gilad AA, Banzhaf W. Computational Peptide Discovery with a Genetic Programming Approach. Res Sq. 2023 Sep 01.
- Lu J, Jerschow A, Korenchan DE. Selective filtration of NMR signals arising from weakly- and strongly-coupled spin systems. J Magn Reson. 2023 09. 354:107529